Haas N, Hamann K, Grabbe J, Cremer B, Czarnetzki B M
Department of Dermatology, Rudolf Virchow Hospital, Free University of Berlin, Germany.
Acta Derm Venereol. 1992 Aug;72(4):271-2.
Epidermal Langerhans' cells have previously been shown to bear IgE molecules, particularly in atopic dermatitis skin. Using two highly specific antibodies against the antibody-binding chain of the high affinity IgE-receptor, 29C6 and 6F7, we here provide evidence that Langerhans' cells express this receptor in both normal skin (foreskin) and in lesional skin of patients with atopic and stasis eczema. A specific antibody against the low affinity IgE-receptor, Tü1, showed only a low expression of this receptor. This finding has important potential functional implications for the role of Langerhans' cells in transepidermal, IgE-mediated allergy.
先前已证明表皮朗格汉斯细胞带有IgE分子，尤其是在特应性皮炎皮肤中。我们使用两种针对高亲和力IgE受体抗体结合链的高度特异性抗体29C6和6F7，在此提供证据表明，朗格汉斯细胞在正常皮肤（包皮）以及特应性和淤积性湿疹患者的皮损皮肤中均表达该受体。一种针对低亲和力IgE受体的特异性抗体Tü1，显示该受体仅低表达。这一发现对于朗格汉斯细胞在经表皮IgE介导的过敏反应中的作用具有重要的潜在功能意义。
