Haas N, Hamann K, Grabbe J, Czarnetzki B M
Department of Dermatology, Rudolf Virchow Hospital, Free University of Berlin, Germany.
Exp Dermatol. 1993 Aug;2(4):157-60. doi: 10.1111/j.1600-0625.1993.tb00025.x.
Langerhans cells in the skin have recently been shown to bind IgE molecules via a high-affinity IgE receptor. Using two specific antibodies, 29C6 and 6F7, against the alpha-chain of the high-affinity IgE receptor, we here demonstrate that Langerhans cells express this receptor in oral mucosa. A specific antibody, Tü1, against the low-affinity IgE receptor showed only low expression of this receptor. High-affinity binding for IgE may be important for induction and support of Langerhans cell-dependent transepithelial IgE-mediated allergic reactions and inflammation.
