Herrera-Marschitz M, Meana J J, Hökfelt T, You Z B, Morino P, Brodin E, Ungerstedt U
Department of Pharmacology, Karolinska Institute, Stockholm, Sweden.
Neuroreport. 1992 Oct;3(10):905-8. doi: 10.1097/00001756-199210000-00021.
The release of striatal cholecystokinin, glutamate, aspartate and dopamine was studied in vivo with microdialysis in decorticated rats, with or without callosotomy. Unlesioned rats were also analysed. Unilateral decortication produced a unilateral decrease in K(+)-stimulated extracellular striatal glutamate and aspartate levels, without decreasing cholecystokinin or dopamine levels. However, following decortication plus callosotomy, basal and K(+)-stimulated extracellular cholecystokinin and glutamate levels were significantly decreased in the striatum ipsilateral to side of decortication. Aspartate levels were bilaterally decreased. These results give evidence for the existence of crossed corticostriatal projections containing releasable cholecystokinin and glutamate.
采用微透析技术在去皮质大鼠体内研究纹状体胆囊收缩素、谷氨酸、天冬氨酸和多巴胺的释放情况，这些大鼠进行了或未进行胼胝体切开术。同时也对未损伤的大鼠进行了分析。单侧去皮质导致K⁺刺激的细胞外纹状体谷氨酸和天冬氨酸水平单侧降低，但不降低胆囊收缩素或多巴胺水平。然而，去皮质加胼胝体切开术后，去皮质侧同侧纹状体的基础及K⁺刺激的细胞外胆囊收缩素和谷氨酸水平显著降低。天冬氨酸水平双侧降低。这些结果证明存在含有可释放的胆囊收缩素和谷氨酸的交叉皮质纹状体投射。
