McKaigue J P, Harron D W
Department of Therapeutics and Pharmacology, Queen's University of Belfast, Northern Ireland.
Clin Pharmacol Ther. 1992 Nov;52(5):511-7. doi: 10.1038/clpt.1992.179.
The effects of rilmenidine, a new centrally acting antihypertensive agent, on a number of tests of autonomic function were investigated in six healthy male volunteers. Baroreflex function (delta RR interval [in milliseconds] with each millimeter of mercury change in systolic blood pressure) was determined in response to changes in pressure after injections of phenylephrine and nitroglycerin. Reflex cardiovascular responses to handgrip and standing, as well as during deep breathing and the Valsalva maneuver, were also investigated. Rilmenidine produced a dose-dependent decrease in blood pressure that was not accompanied by an increase in heart rate. Under conditions of low basal sympathetic activity, rilmenidine enhanced parasympathetic tone during the early reflex heart rate changes that occur immediately after standing and during deep breathing, as well as baroreflex heart rate responses to phenylephrine. During a test of sympathetic function, standing blood pressure, and heart rate after 3 minutes, rilmenidine reduced sympathetic tone.
在6名健康男性志愿者中研究了新型中枢性抗高血压药物利美尼定对多项自主神经功能测试的影响。通过注射去氧肾上腺素和硝酸甘油后压力变化来测定压力反射功能（收缩压每变化1毫米汞柱时RR间期的变化[以毫秒为单位]）。还研究了对手握力、站立以及深呼吸和瓦尔萨尔瓦动作时的反射性心血管反应。利美尼定使血压呈剂量依赖性下降，且不伴有心率增加。在基础交感神经活动较低的情况下，利美尼定在站立后和深呼吸后立即出现的早期反射性心率变化以及对去氧肾上腺素的压力反射性心率反应期间增强了副交感神经张力。在交感神经功能测试中，站立3分钟后的血压和心率，利美尼定降低了交感神经张力。
