Spiers J P, Harron D W, Wilson R
Department of Therapeutics and Pharmacology, Queen's University of Belfast, Northern Ireland.
Eur J Pharmacol. 1990 Jun 8;181(3):235-40. doi: 10.1016/0014-2999(90)90083-i.
The effects of acute and chronic administration of rilmenidine on blood pressure, heart rate and baroreflex function were assessed in two groups of six conscious dogs. Baroreflex function was evaluated using increasing doses of glyceryl trinitrate and phenylephrine to decrease and increase blood pressure respectfully. Acute administration of rilmenidine (1 mg/kg p.o.) reduced (P less than 0.05) blood pressure and heart rate, and enhanced (P less than 0.05) baroreflex function to increases in blood pressure with phenylephrine, but not to decreases in blood pressure by glyceryl trinitrate. Following chronic administration of rilmenidine, blood pressure remained lowered while heart rate and baroreflex function returned to control values.
在两组各6只清醒犬中评估了利美尼定急性和慢性给药对血压、心率和压力反射功能的影响。使用递增剂量的硝酸甘油和去氧肾上腺素分别降低和升高血压来评估压力反射功能。利美尼定急性给药（口服1mg/kg）可降低（P<0.05）血压和心率，并增强（P<0.05）压力反射功能，使去氧肾上腺素引起的血压升高时的压力反射功能增强，但对硝酸甘油引起的血压降低时的压力反射功能无增强作用。利美尼定慢性给药后，血压仍降低，而心率和压力反射功能恢复至对照值。
