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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Ferrer X, Moreno J J

Departamento Ciencias Fisiológicas Humanas y de la Nutrición, Univ. Barcelona, Spain.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1992 Jun;102(2):325-7. doi: 10.1016/0742-8413(92)90119-r.

Intradermal or subplantar injection of soluble snake venom phospholipase A2 (PLA2) evoked a brisk inflammatory response, with cutaneous vascular permeability increase and paw oedema. 2. These inflammatory processes are mainly the result of arachidonic acid cascade activation and mast cell degranulation. 3. Copper, iron and zinc have an inhibitory effect on vascular permeability increase and paw oedema induced by PLA2. 4. Copper and iron could have not only a direct effect on PLA2 but on enzymes of arachidonic acid cascade. 5. However, zinc have a moderate antiinflammatory activity. This effect could be the result to inhibit PLA2 induced mast cell degranulation.

皮内或足底注射可溶性蛇毒磷脂酶A2（PLA2）可引发快速的炎症反应，伴有皮肤血管通透性增加和爪部水肿。2. 这些炎症过程主要是花生四烯酸级联反应激活和肥大细胞脱颗粒的结果。3. 铜、铁和锌对PLA2诱导的血管通透性增加和爪部水肿具有抑制作用。4. 铜和铁不仅可能对PLA2有直接作用，还可能对花生四烯酸级联反应的酶有作用。5. 然而，锌具有中等程度的抗炎活性。这种作用可能是抑制PLA2诱导的肥大细胞脱颗粒的结果。

Ferrer X, Moreno J J

Departamento Ciencias Fisiológicas Humanas y de la Nutrición, Univ. Barcelona, Spain.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1992 Jun;102(2):325-7. doi: 10.1016/0742-8413(92)90119-r.

Intradermal or subplantar injection of soluble snake venom phospholipase A2 (PLA2) evoked a brisk inflammatory response, with cutaneous vascular permeability increase and paw oedema. 2. These inflammatory processes are mainly the result of arachidonic acid cascade activation and mast cell degranulation. 3. Copper, iron and zinc have an inhibitory effect on vascular permeability increase and paw oedema induced by PLA2. 4. Copper and iron could have not only a direct effect on PLA2 but on enzymes of arachidonic acid cascade. 5. However, zinc have a moderate antiinflammatory activity. This effect could be the result to inhibit PLA2 induced mast cell degranulation.

皮内或足底注射可溶性蛇毒磷脂酶A2（PLA2）可引发快速的炎症反应，伴有皮肤血管通透性增加和爪部水肿。2. 这些炎症过程主要是花生四烯酸级联反应激活和肥大细胞脱颗粒的结果。3. 铜、铁和锌对PLA2诱导的血管通透性增加和爪部水肿具有抑制作用。4. 铜和铁不仅可能对PLA2有直接作用，还可能对花生四烯酸级联反应的酶有作用。5. 然而，锌具有中等程度的抗炎活性。这种作用可能是抑制PLA2诱导的肥大细胞脱颗粒的结果。