Moreno J J
Departamento de Ciencias Fisiológicas, Fac. Farmacia, Univ. Barcelona, Spain.
Immunopharmacology. 1993 Jul-Aug;26(1):1-9. doi: 10.1016/0162-3109(93)90061-t.
Recently, it has been reported that aristolochic acid inhibits phospholipase A2 (PLA2) in vitro and also decrease either oedema induced by snake venom and human synovial fluid PLA2. The aim of this research was to study the antiinflammatory activity of aristolochic acid and to investigate the effect of the alkaloid on the enzymes involved in the release of eicosanoids. Our results demonstrate that aristolochic acid is able to inhibit inflammation induced by immunological, immune complexes, and nonimmunological agents such as carrageenan or croton oil. We suggest that one mechanism of the antiinflammatory activity of alkaloid may be by directly blocking PLA2 catalyzed release of arachidonic acid. Moreover, this study demonstrates that aristolochic acid could also inhibit other steps involved in eicosanoids release such as cyclooxygenase and lipooxygenase pathways.
最近，有报道称马兜铃酸在体外可抑制磷脂酶A2（PLA2），还能减轻蛇毒和人滑液PLA2诱导的水肿。本研究的目的是研究马兜铃酸的抗炎活性，并探讨该生物碱对参与类花生酸释放的酶的影响。我们的结果表明，马兜铃酸能够抑制由免疫、免疫复合物以及角叉菜胶或巴豆油等非免疫剂诱导的炎症。我们认为生物碱抗炎活性的一种机制可能是直接阻断PLA2催化的花生四烯酸释放。此外，本研究表明马兜铃酸还可抑制类花生酸释放过程中涉及的其他步骤，如环氧合酶和脂氧合酶途径。
