Forrester J V, Liversidge J, Dua H S, Dick A, Harper F, McMenamin P G
Department of Opthalmology, University of Aberdeen, Medical School, Foresterhill, UK.
Curr Eye Res. 1992;11 Suppl:33-40. doi: 10.3109/02713689208999509.
Experimental autoimmune uveoretinitis (EAU) is a useful model of human posterior uveitis and as such, permits the analysis of strategies for immuno-intervention. Modulation of the autoimmune response may be attempted at the stages of induction of EAU, during homing of autoreactive lymphocytes to the target organ, the retina, or during the effector stage of the disease. This paper presents a brief overview of current immuno-therapeutic modalities and assesses the usefulness for extrapolation to human disease.
实验性自身免疫性葡萄膜视网膜炎（EAU）是人类后葡萄膜炎的一种有用模型，因此可以用于分析免疫干预策略。可以在EAU诱导阶段、自身反应性淋巴细胞归巢至靶器官视网膜的过程中或疾病的效应阶段尝试调节自身免疫反应。本文简要概述了当前的免疫治疗方法，并评估了将其外推至人类疾病的实用性。
