氯化汞注射大鼠实验性自身免疫性葡萄膜视网膜炎的过继转移

Adoptive transfer of experimental autoimmune uveoretinitis in HgCl2 injected rats.

作者信息

Saoudi A, Bellon B, de Kozak Y, Druet P

机构信息

Pathologie rénale et vasculaire, INSERM U28, Hôpital Broussais, Paris, France.

出版信息

Curr Eye Res. 1992;11 Suppl:101-5. doi: 10.3109/02713689208999518.

DOI:10.3109/02713689208999518

PMID:1424735

Abstract

We previously demonstrated that mercuric chloride (HgCl2) injected-(Lewis x Brown-Norway) F1 rats are protected against experimental autoimmune uveoretinitis (EAU) induced by active immunization with the retinal S-antigen (S-Ag). To better understand the mechanisms of the protection promoted by HgCl2, we studied the effect of HgCl2-induced autoimmune disease on transferred EAU. We demonstrate herein that HgCl2 has no effect on adoptively transferred EAU. Therefore, the HgCl2-induced autoimmune disease does not affect effector S-Ag specific T cells activated in vitro but acts at an earlier stage.

摘要

我们之前证明，向（Lewis×Brown-Norway）F1大鼠注射氯化汞（HgCl2）可使其免受因用视网膜S抗原（S-Ag）主动免疫诱导的实验性自身免疫性葡萄膜视网膜炎（EAU）的侵害。为了更好地理解HgCl2所促进的保护机制，我们研究了HgCl2诱导的自身免疫性疾病对转移型EAU的影响。我们在此证明，HgCl2对过继转移的EAU没有影响。因此，HgCl2诱导的自身免疫性疾病并不影响体外激活的效应性S-Ag特异性T细胞，而是在更早阶段起作用。