Sanchez-Fernandez de Sevilla M C, Gil-Salmon M, Perez-Bacete M, Morell-Quadreny L, Martinez-Diaz F, Iborra-Juan I, Fenollosa-Entrena B, Llombart-Bosch A
Department of Pathology, University of Valencia, Spain.
Eur Urol. 1992;21 Suppl 1:16-21. doi: 10.1159/000474881.
We carried out a DNA-ploidy, morphometric-stereologic and P-glycoprotein study on 40 newly diagnosed superficial bladder cancer patients (G1-G2), correlating the results with histological grade and clinical outcome. Variations in the number of patients who present recurrences, progression or remain tumor-free during the whole follow-up period (at least 5 years) were not significant when related to nuclear size, proliferative diploid index, presence of aneuploidy and expression of P-glycoprotein. It is striking how the majority of disease-free subjects showed a proliferative diploid index higher than 10%. Moreover, 3 of them presented an aneuploid cell population. In our study, only histological grade showed a significant discriminatory level in terms of progression versus no progression in patients with superficial bladder cancer.
我们对40例新诊断的浅表性膀胱癌患者（G1-G2）进行了DNA倍体、形态计量学-体视学和P-糖蛋白研究，并将结果与组织学分级和临床结果相关联。在整个随访期（至少5年）内，复发、进展或无瘤生存的患者数量变化，与细胞核大小、增殖性二倍体指数、非整倍体的存在及P-糖蛋白的表达无关，差异无统计学意义。值得注意的是，大多数无瘤患者的增殖性二倍体指数高于10%。此外，其中3例存在非整倍体细胞群。在我们的研究中，对于浅表性膀胱癌患者，只有组织学分级在进展与无进展方面显示出显著的鉴别水平。
