人结肠癌中腱生蛋白表达、DNA倍体模式与多药耐药基因产物（P-糖蛋白）之间的关系

Relationships among tenascin expression, DNA ploidy patterns, and multidrug resistance gene product (P-glycoprotein) in human colon carcinoma.

作者信息

Sugawara I, Hirakoshi J, Kusakabe M, Masunaga A, Itoyama S, Sakakura T

机构信息

Department of Pathology, Saitama Medical Center, Saitama Medical School.

出版信息

Jpn J Cancer Res. 1993 Jul;84(7):703-7. doi: 10.1111/j.1349-7006.1993.tb02032.x.

DOI:10.1111/j.1349-7006.1993.tb02032.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5919212/

Abstract

Relationships among tenascin expression, DNA ploidy, and P-glycoprotein were examined in 81 primary human colon cancers and 61 metastatic lymph nodes. First, the DNA ploidy patterns of colon cancerous tissue surrounded (TN+) and not surrounded (TN-) by tenascin immunoreactivity were investigated. Then the expression of P-glycoprotein, one of two multidrug resistance gene products, was examined in TN+ and TN- colon cancer tissues by immunohistochemistry. Aneuploid DNA patterns were observed at high frequency in TN- colon cancer tissues (37/61) and metastatic lymph nodes (44/52). In contrast, diploid DNA patterns were observed predominantly in TN+ colon cancer tissues (50/56). Although P-glycoprotein expression was observed in primary TN+ and TN- colon cancer (9/81), the level of P-glycoprotein expression was not correlated with DNA aneuploidy in TN- colon cancer tissues. Overall, reduced tenascin expression was correlated well with DNA aneuploidy, but no significant correlation was found between DNA aneuploidy and P-glycoprotein appearing when cancer cells become resistant to several anti-cancer drugs. Thus, tenascin may play an important role in preventing colon cancer cells from invading surrounding tissues.

摘要

在81例原发性人类结肠癌和61个转移性淋巴结中，研究了腱生蛋白表达、DNA倍体和P-糖蛋白之间的关系。首先，研究了被腱生蛋白免疫反应包围（TN+）和未被包围（TN-）的结肠癌组织的DNA倍体模式。然后，通过免疫组织化学检测TN+和TN-结肠癌组织中两种多药耐药基因产物之一的P-糖蛋白的表达。在TN-结肠癌组织（37/61）和转移性淋巴结（44/52）中高频观察到非整倍体DNA模式。相比之下，在TN+结肠癌组织（50/56）中主要观察到二倍体DNA模式。虽然在原发性TN+和TN-结肠癌中观察到P-糖蛋白表达（9/81），但在TN-结肠癌组织中P-糖蛋白表达水平与DNA非整倍体无关。总体而言，腱生蛋白表达降低与DNA非整倍体密切相关，但在癌细胞对几种抗癌药物产生耐药性时出现的DNA非整倍体与P-糖蛋白之间未发现显著相关性。因此，腱生蛋白可能在防止结肠癌细胞侵袭周围组织中起重要作用。

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