Ferrari F, Pelloni F, Giuliani D
Institute of Pharmacology, University of Modena, Italy.
Eur J Pharmacol. 1992 Jun 17;216(3):345-50. doi: 10.1016/0014-2999(92)90429-8.
The effect of the D2 agonist B-HT 920 was examined on three behavioural models of induced grooming in the rat. B-HT 920 potently inhibited the grooming elicited by a novel environment, whereas it stimulated the stretching-yawning syndrome. Pretreatment with the selective dopamine D2 receptor antagonist, sulpiride, reversed the phenomenon. When B-HT 920 was administered to rats before water immersion, it similarly antagonized total grooming; wet-dog shakes, detected in these same animals, were potently inhibited. Finally, B-HT 920 displayed inhibitory activity towards adrenocorticotropin hormone-induced excessive grooming. On the basis of these effects, the role of D2 receptor subtypes in the modulation of grooming is discussed.
研究了D2激动剂B-HT 920对大鼠三种诱导梳理行为模型的影响。B-HT 920能有效抑制由新环境引发的梳理行为，而刺激了伸展-打哈欠综合征。用选择性多巴胺D2受体拮抗剂舒必利预处理可逆转该现象。在水浸前给大鼠注射B-HT 920，同样能拮抗总的梳理行为；在这些动物中检测到的湿狗样抖动被有效抑制。最后，B-HT 920对促肾上腺皮质激素诱导的过度梳理表现出抑制活性。基于这些效应，讨论了D2受体亚型在梳理行为调节中的作用。
