Ferrari F, Pelloni F, Filaferro M, Giuliani D
Institute of Pharmacology, University of Modena, Italy.
Life Sci. 1992;50(14):1013-9. doi: 10.1016/0024-3205(92)90096-8.
The D2 autoreceptor agonist B-HT 958, intraperitoneally injected into Wistar male rats in a novel environment, significantly increased stretching and yawning (SY) while inhibiting grooming. Pretreatment with the D2 antagonist sulpiride reversed these effects, antagonizing SY and restoring grooming. Similarly, when B-HT 958 was administered to rats in their home cages, it elicited SY and abolished grooming; moreover, when administered before the i.c.v. injection of adrenocorticotropin hormone, dose-dependently enhanced SY and strongly antagonized the typical syndrome of intensified grooming induced by the peptide. The possible relationship between SY and grooming and the involvement of D2 autoreceptors are discussed.
在新环境中腹腔注射D2自受体激动剂B-HT 958至Wistar雄性大鼠体内，显著增加了伸展和打哈欠（SY）行为，同时抑制了梳理行为。用D2拮抗剂舒必利预处理可逆转这些效应，对抗SY并恢复梳理行为。同样，当在大鼠的饲养笼中给其注射B-HT 958时，会引发SY并消除梳理行为；此外，在脑室内注射促肾上腺皮质激素之前给药，剂量依赖性地增强了SY，并强烈对抗了该肽诱导的典型的梳理行为增强综合征。文中讨论了SY与梳理行为之间可能的关系以及D2自受体的参与情况。
