Tadmor O P, Kleinman Y, Goldstein R, Diamant Y Z
Department of Gynecology, Shaare Zedek Medical Center, Jerusalem, Israel.
Int J Gynaecol Obstet. 1992 Oct;39(2):105-10. doi: 10.1016/0020-7292(92)90905-x.
To determine the effect of a hormone replacement protocol containing conjugated equine estrogens and desogestrel (which has a highly selective progestogenic and low androgenic effect) as the progestogen, on the plasma lipid profile, as compared with two other hormone replacement treatments (HRT).
Eighty-nine healthy postmenopausal women were divided prospectively into four groups. A control group of 24 women did not receive HRT. Twenty-nine women received conjugated equine estrogen and medroxyprogesterone, and 13 women received a protocol containing estradiol, estriol and norethisterone acetate. Fasting blood lipid was taken at the end of each third cycle. The cumulative therapeutic response was calculated in each group as compared with initial values and between groups. Significance was analyzed by t-tests.
A protocol containing desogestrel significantly decreased low-density lipoprotein cholesterol (27%; P < 0.05) and increased high-density lipoprotein cholesterol (HDL-C) by 30% (P < 0.05%) after 9 months. The ratio of total cholesterol to HDL-C also decreased significantly (44%; P < 0.05).
The most beneficial effect on plasma lipid profile was obtained with an HRT protocol containing desogestrel as the progesterone.
确定一种以结合马雌激素和去氧孕烯（具有高度选择性孕激素作用且雄激素作用低）作为孕激素的激素替代方案，与其他两种激素替代疗法（HRT）相比，对血浆脂质谱的影响。
八十九名健康绝经后妇女被前瞻性地分为四组。24名妇女组成的对照组未接受HRT。29名妇女接受结合马雌激素和甲羟孕酮治疗，13名妇女接受含有雌二醇、雌三醇和醋酸炔诺酮的方案治疗。在每第三个周期结束时采集空腹血脂。计算每组与初始值以及组间的累积治疗反应。通过t检验分析显著性。
含有去氧孕烯的方案在9个月后显著降低低密度脂蛋白胆固醇（27%；P < 0.05），并使高密度脂蛋白胆固醇（HDL-C）升高30%（P < 0.05%）。总胆固醇与HDL-C的比值也显著降低（44%；P < 0.05）。
以去氧孕烯作为孕激素的HRT方案对血浆脂质谱的有益作用最为显著。
