Ogierman M A, Manning P A
Department of Microbiology and Immunology, University of Adelaide, Australia.
FEMS Microbiol Lett. 1992 Oct 1;76(1-2):179-84. doi: 10.1016/0378-1097(92)90383-y.
The nucleotide sequence of the tcpC gene has been determined. It encodes a 53995-Da protein precursor with a signal sequence and cleavage site typical of a number of outer membrane lipoproteins, which are cleaved by the equivalent of signal peptidase II (Lsp) of Escherichia coli. The location of the tcpC gene is such that it is predicted to be translationally coupled to the 5' and 3' flanking genes, tcpY and tcpD, respectively, indicating that it forms part of an operon. Together with the lipoprotein signal sequence and the several hydrophobic domains it seems likely that TcpC is a surface-anchored trans-outer membrane lipoprotein.
tcpC基因的核苷酸序列已被确定。它编码一个53995道尔顿的蛋白质前体，带有一个信号序列和切割位点，这是许多外膜脂蛋白所特有的，这些外膜脂蛋白会被相当于大肠杆菌信号肽酶II（Lsp）的酶切割。tcpC基因的位置表明，预计它分别与5'和3'侧翼基因tcpY和tcpD翻译偶联，这表明它是一个操纵子的一部分。连同脂蛋白信号序列和几个疏水结构域，TcpC似乎很可能是一种表面锚定的跨外膜脂蛋白。
