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一个原发性高血压发病率高的日本家族中的肾素基因限制性片段长度多态性

Renin gene restriction fragment length polymorphisms in a Japanese family with a high incidence of essential hypertension.

作者信息

Okura T, Kitami Y, Wakamiya R, Iwata T, Hiwada K

机构信息

2nd Department of Internal Medicine, Ehime University School of Medicine, Japan.

出版信息

Clin Exp Pharmacol Physiol Suppl. 1992;20:17-9.

PMID:1359934
Abstract
  1. Human renin gene restriction fragment length polymorphisms (RFLP) were compared in a Japanese family which has a high incidence of essential hypertension. 2. RFLP of human renin gene were observed in three restriction enzymes, Mbo I, Bgl I and Hind III; 1.4 kb and 1.0 kb [Mbo I], 5.0 kb and 9.0 kb [Bgl I] and 9.0 and 6.2 kb [Hind III]. 3. Plasma renin activity was not associated with blood pressure. 4. Renin gene RFLP were not cosegregated with essential hypertension in this Japanese family.
摘要
  1. 在一个原发性高血压发病率很高的日本家族中，对人类肾素基因限制性片段长度多态性（RFLP）进行了比较。2. 在三种限制性内切酶Mbo I、Bgl I和Hind III中观察到了人类肾素基因的RFLP；1.4 kb和1.0 kb[Mbo I]、5.0 kb和9.0 kb[Bgl I]以及9.0和6.2 kb[Hind III]。3. 血浆肾素活性与血压无关。4. 在这个日本家族中，肾素基因RFLP与原发性高血压不共分离。

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