Fu Y, Katsuya T, Asai T, Fukuda M, Inamoto N, Iwashima Y, Sugimoto K, Rakugi H, Higaki J, Ogihara T
Department of Geriatric Medicine, Osaka University Medical School, Suita, Japan.
Hypertens Res. 2001 May;24(3):295-8. doi: 10.1291/hypres.24.295.
Predisposition to essential hypertension is associated with gene polymorphisms of the renin angiotensin system (RAS). Gene polymorphisms of the angiotensinogen and angiotensin converting enzyme genes are known to be risk factors for hypertension, while few studies concerning the renin gene polymorphism have been published. In the present investigation, we carried out a case control study using a Japanese population to examine the genetic influence of the renin gene on the predisposition to hypertension. Patients (n=235) recruited from outpatients at Osaka University Hospital and diagnosed with essential hypertension or receiving long-term antihypertensive medication participated in the study. Normotensive control subjects (n=510) without a history of hypertension and without diabetes mellitus were recruited from the same population, and were sex-matched with experimental subjects. A polymorphism in intron 9 of the human renin gene was determined as the Mbo I restriction fragment length polymorphism (Mbo I-RFLP). There was no significant association between Mbo I-RFLP of the renin gene and predisposition to essential hypertension in Japanese (p>0.05, chi2=2.1). These results suggest that the Mbo I (+) allele of the renin gene does not increase the risk for hypertension in Japanese.
原发性高血压的易感性与肾素血管紧张素系统（RAS）的基因多态性有关。已知血管紧张素原和血管紧张素转换酶基因的多态性是高血压的危险因素，而关于肾素基因多态性的研究报道较少。在本研究中，我们采用日本人群进行病例对照研究，以探讨肾素基因对高血压易感性的遗传影响。从大阪大学医院门诊招募的患者（n = 235）参与了本研究，这些患者被诊断为原发性高血压或正在接受长期抗高血压治疗。从同一人群中招募了无高血压病史且无糖尿病的血压正常对照者（n = 510），并按性别与实验对象匹配。人类肾素基因第9内含子的多态性被确定为Mbo I限制性片段长度多态性（Mbo I-RFLP）。在日本人中，肾素基因的Mbo I-RFLP与原发性高血压易感性之间无显著关联（p>0.05，χ2 = 2.1）。这些结果表明，肾素基因的Mbo I（+）等位基因不会增加日本人患高血压的风险。
