McCarthy M I, Hitman G A, Mohan V, Ramachandran A, Snehalatha C, Viswanathan M
Cellular Mechanisms Group, London Hospital Medical College, United Kingdom.
Diabetes Res Clin Pract. 1992 Oct;18(1):31-4. doi: 10.1016/0168-8227(92)90052-s.
Islet amyloid polypeptide (IAPP), otherwise called amylin, is the monomeric component of islet amyloid. Deposition of this amyloid is a characteristic feature of non-insulin-dependent diabetes mellitus in humans and may play a role in the pathogenesis of the disease. As such, abnormalities in the structure or expression of the IAPP gene might contribute to the inheritance of this condition. The IAPP gene was studied in a well-characterised population of 62 unrelated Dravidian subjects with non-insulin-dependent diabetes mellitus and 56 normal Dravidian controls, using a restriction fragment length polymorphism generated by PvuII digestion. Genotype and allele frequencies did not differ between diabetic subjects and controls. Taken together with recent findings in Europid and other racial groups, an abnormality of the IAPP gene is highly unlikely to represent a major gene for the development of non-insulin-dependent diabetes mellitus.
胰岛淀粉样多肽（IAPP），又称胰淀素，是胰岛淀粉样物质的单体成分。这种淀粉样物质的沉积是人类非胰岛素依赖型糖尿病的一个特征性表现，并且可能在该疾病的发病机制中起作用。因此，IAPP基因结构或表达的异常可能导致这种疾病的遗传。我们使用由PvuII酶切产生的限制性片段长度多态性，在62名无亲缘关系的患非胰岛素依赖型糖尿病的达罗毗荼人受试者以及56名正常达罗毗荼人对照组成的特征明确的人群中研究了IAPP基因。糖尿病受试者和对照组之间的基因型和等位基因频率没有差异。结合最近在欧洲人及其他种族群体中的研究结果，IAPP基因异常极不可能是导致非胰岛素依赖型糖尿病发生的主要基因。
