Dundee J W, George K A
Acta Anaesthesiol Belg. 1976;27 suppl:3-11.
Studies in man show that it is possible to reliably study the incidence, degree and duration of amnesia produced by drugs by showing patients 10 postcards and testing their ability to recall or recognise them six hours later. Using this method of study it was found that 1 mg flunitrazepam produced a comparable degree of amnesia to 10 mg diazepam, although its action was slightly longer. This difference was more marked when double doses were studied. The onset of the amnesic action of both drugs occurred within 2 minutes of their intravenous injection and rarely persisted for more than 10-15 minutes. In contrast, with 4 mg lorazepam the onset of amnesia was slower and persisted for up to 270 minutes. This was accompanied by a moderate but not excessive amount of drowsiness. Possible clinical uses for such a drug deserve serious consideration.
人体研究表明，通过向患者展示10张明信片，并在6小时后测试他们回忆或识别明信片的能力，能够可靠地研究药物所致失忆症的发生率、程度和持续时间。采用这种研究方法发现，1毫克氟硝西泮产生的失忆程度与10毫克地西泮相当，尽管其作用时间稍长。研究双倍剂量时，这种差异更为明显。两种药物失忆作用的起效时间均在静脉注射后2分钟内，且很少持续超过10 - 15分钟。相比之下，4毫克劳拉西泮引起失忆的起效较慢，且持续长达270分钟。同时伴有中度但并不过度的嗜睡。这种药物可能的临床用途值得认真考虑。
