Healey M, Pickens R, Meisch R, McKenna T
J Clin Psychiatry. 1983 Dec;44(12):436-9.
Healthy adults (N = 10) were given oral doses of lorazepam (1 and 2 mg), diazepam (5 and 10 mg), clorazepate (7.5 and 15 mg), or placebo and tested 30, 60, 90, and 120 minutes later on a word-recall memory task. All subjects received each drug dose once and placebo twice in randomized order at weekly intervals. Testing was double-blind. Lorazepam was found to have a significantly greater effect on memory than placebo. Diazepam and clorazepate did not differ significantly from placebo in their effect on word recall. High doses of lorazepam produced more pronounced memory effects than did low doses; neither diazepam nor clorazepate was found to exert a dose-related effect on memory.
健康成年人（N = 10）口服洛拉佐epam（1毫克和2毫克）、地西泮（5毫克和10毫克）、氯氮卓（7.5毫克和15毫克）或安慰剂，30、60、90和120分钟后在单词回忆记忆任务中进行测试。所有受试者按随机顺序每周接受一次每种药物剂量和两次安慰剂。测试为双盲。发现洛拉佐epam对记忆的影响明显大于安慰剂。地西泮和氯氮卓在对单词回忆的影响上与安慰剂没有显著差异。高剂量的洛拉佐epam比低剂量产生更明显的记忆效果；未发现地西泮和氯氮卓对记忆有剂量相关的影响。
