Pandit S K, Heisterkamp D V, Cohen P J
Anesthesiology. 1976 Nov;45(5):495-500.
The time of onset and duration of the anti-recall action of lorazepam were assessed under clinical conditions by measuring recall and recognition of visual stimuli 24 hours after intravenous administration of lorazepam. The visual stimuli were first presented 5-240 minutes after 2 mg and 5-360 minutes after 4 mg lorazepam. Retrograde amnesia was not produced. Lorazepam, 2 mg, produced a short anti-recall effect (anterograde amnesia) in 50 per cent of the cases, with a latency of 30 minutes and a duration of less than half an hour. Duration and frequency of the anti-recall effect were greater after 4 mg, while the latency was shorter. More than 70 per cent of the individuals tested were amnesic for the visual stimuli 15 minutes to 4 hours after 4 mg lorazepam. Sedation was satisfactory and long-lasting following both doses of lorazepam, but was not related to the anti-recall effect.
在临床条件下，通过测量静脉注射劳拉西泮24小时后对视觉刺激的回忆和识别，评估劳拉西泮抗回忆作用的起效时间和持续时间。视觉刺激在2毫克劳拉西泮给药后5至240分钟首次呈现，在4毫克劳拉西泮给药后5至360分钟首次呈现。未产生逆行性遗忘。2毫克劳拉西泮在50%的病例中产生了短暂的抗回忆作用（顺行性遗忘），潜伏期为30分钟，持续时间不到半小时。4毫克给药后，抗回忆作用的持续时间和频率更长，而潜伏期更短。在4毫克劳拉西泮给药后15分钟至4小时，超过70%的受试个体对视觉刺激存在遗忘。两种剂量的劳拉西泮给药后镇静效果均令人满意且持久，但与抗回忆作用无关。
