Wilckens T, Schweiger U, Pirke K M
Max-Planck-Institut for Psychiatry, München, Germany.
Pharmacol Biochem Behav. 1992 Nov;43(3):733-8. doi: 10.1016/0091-3057(92)90402-2.
Male Wistar rats were housed in cages linked to running wheels and fed on a schedule designed to reduce their body weight by 20-30%. During this period of semistarvation, rats increased their daily running wheel activity (RWA) by up to 30 km/day. RWA could be kept at this level provided that body weight was kept constant. Different alpha-adrenergic agonists and antagonists were tested for their effects on RWA and it was found that RWA could be suppressed only by agonists that display high affinity for the alpha 2-receptor (clonidine and guanfacine). Neither antagonist had an effect on RWA. Clonidine's inhibiting effect on RWA was prevented by pretreatment with yohimbine, which also has high affinity for alpha 2-receptors. From these results, we conclude that semistarvation-induced hyperactivity can be blocked by alpha 2-agonists. In view of this result and those that were obtained in previous studies, a theoretical model for the development of semistarvation-induced hyperactivity will be presented.
雄性Wistar大鼠饲养在与跑轮相连的笼子里，并按照旨在使其体重减轻20% - 30%的时间表进食。在半饥饿期间，大鼠每天的跑轮活动（RWA）增加了高达30公里/天。只要体重保持恒定，RWA就能维持在这个水平。测试了不同的α - 肾上腺素能激动剂和拮抗剂对RWA的影响，发现只有对α2受体具有高亲和力的激动剂（可乐定和胍法辛）才能抑制RWA。两种拮抗剂对RWA均无影响。育亨宾对RWA的抑制作用可被预先处理所阻断，育亨宾对α2受体也具有高亲和力。从这些结果中，我们得出结论，半饥饿诱导的多动可被α2激动剂阻断。鉴于这一结果以及先前研究中获得的结果，将提出一个半饥饿诱导多动发展的理论模型。
