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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Robertson B E, Kozlowski R Z, Nye P C

University Laboratory of Physiology, Oxford, UK.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1992 Jul;102(3):459-62. doi: 10.1016/0742-8413(92)90143-u.

We show that cromakalin and diazoxide, drugs that activate ATP-sensitive potassium (KATP) channels, abolish hypoxic pulmonary vasoconstriction (HPV) of isolated, perfused rat lungs. 2. Glibenclamide, an inhibitor of these channels, does not affect HPV, but it reverses the relaxation caused by cromakalim and diazoxide. 3. Tolbutamide, which has effects similar to glibenclamide in other tissues, paradoxically abolishes HPV, an effect reversed by glibenclamide. 4. These results suggest that: (i) pulmonary vessels contain KATP channels which are normally closed and are not opened by levels of hypoxia that cause constriction, (ii) tolbutamide acts on the pulmonary vasculature by a mechanism which differs from that of glibenclamide.

我们发现，可激活三磷酸腺苷敏感性钾（KATP）通道的药物克罗卡林和二氮嗪，可消除离体灌注大鼠肺脏的低氧性肺血管收缩（HPV）。2. 这些通道的抑制剂格列本脲不影响HPV，但可逆转克罗卡林和二氮嗪引起的舒张作用。3. 甲苯磺丁脲在其他组织中具有与格列本脲相似的作用，但矛盾的是它可消除HPV，而这种作用可被格列本脲逆转。4. 这些结果表明：（i）肺血管含有KATP通道，这些通道通常是关闭的，不会因导致血管收缩的低氧水平而打开；（ii）甲苯磺丁脲作用于肺血管的机制与格列本脲不同。

Robertson B E, Kozlowski R Z, Nye P C

University Laboratory of Physiology, Oxford, UK.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1992 Jul;102(3):459-62. doi: 10.1016/0742-8413(92)90143-u.

We show that cromakalin and diazoxide, drugs that activate ATP-sensitive potassium (KATP) channels, abolish hypoxic pulmonary vasoconstriction (HPV) of isolated, perfused rat lungs. 2. Glibenclamide, an inhibitor of these channels, does not affect HPV, but it reverses the relaxation caused by cromakalim and diazoxide. 3. Tolbutamide, which has effects similar to glibenclamide in other tissues, paradoxically abolishes HPV, an effect reversed by glibenclamide. 4. These results suggest that: (i) pulmonary vessels contain KATP channels which are normally closed and are not opened by levels of hypoxia that cause constriction, (ii) tolbutamide acts on the pulmonary vasculature by a mechanism which differs from that of glibenclamide.

我们发现，可激活三磷酸腺苷敏感性钾（KATP）通道的药物克罗卡林和二氮嗪，可消除离体灌注大鼠肺脏的低氧性肺血管收缩（HPV）。2. 这些通道的抑制剂格列本脲不影响HPV，但可逆转克罗卡林和二氮嗪引起的舒张作用。3. 甲苯磺丁脲在其他组织中具有与格列本脲相似的作用，但矛盾的是它可消除HPV，而这种作用可被格列本脲逆转。4. 这些结果表明：（i）肺血管含有KATP通道，这些通道通常是关闭的，不会因导致血管收缩的低氧水平而打开；（ii）甲苯磺丁脲作用于肺血管的机制与格列本脲不同。