对主要组织相容性复合体内B基因座与D基因座之间重组频率的估计。
An estimate of the recombination frequency between the B locus and the D locus within the major histocompatibility complex.
作者信息
Mickelson E M, Petersons J S, Flournoy N, Clift R A, Thomas E D
出版信息
Tissue Antigens. 1976 Oct;8(4):247-52.
Mixed leukocyte culture studies on 120 families, including 120 HLA haplo-identical siblings and 210 HLA-identical siblings, were analyzed for unusual patterns of reactivity. Three discrepant reactions were noted in which cells from HLA-identical siblings showed strong mutual stimulation. These data provide an estimate of 0.0065 as the recombination frequency between the HLA-B and HLA-D regions of the major histocompatibility chromosome in man. When combined with the data of Keuning et al. (1975), the value is 0.0068 with a 95% confidence interval of 0.0022 to 0.0158.
对120个家庭进行了混合淋巴细胞培养研究，其中包括120名HLA单倍型相同的同胞和210名HLA相同的同胞，分析其异常的反应模式。发现了三例不一致的反应，即来自HLA相同同胞的细胞表现出强烈的相互刺激。这些数据估计人类主要组织相容性染色体的HLA - B和HLA - D区域之间的重组频率为0.0065。与Keuning等人（1975年）的数据相结合，该值为0.0068，95%置信区间为0.0022至0.0158。
Zotero 插件