Tong G X, Zhao B G, Wang Z X, Gu D Y, Luo L G, Cheng Z P
Sheng Li Xue Bao. 1992 Jun;44(3):269-74.
The effect of exogenous opioid peptides on progesterone production by incubated rat luteal cells was studied. beta-endorphin (beta-EP) stimulated progesterone production in a dose-dependant manner (10(-8)-10(-6) mol/L); dynorphin exhibited a stimulatory effect only at 10(-6) mol/L, while Met-enkephalin had no substantial effect at dose from 10(-10)-10(-6) mol/L. mu-opioid receptor agonists DAGO and morphine also stimulated progesterone production. The stimulatory actions of beta-EP, DAGO and morphine were reversed completely by naloxone. On account of the fact that the beta-EP level in rat plasma is lower than that in the ovary, it seemed that beta-EP may be an intra-ovarian luteotrophic factor and be involved in the regulation of progesterone production. This action of beta-EP may be mediated by mu-opioid subtype receptors.
研究了外源性阿片肽对体外培养的大鼠黄体细胞孕酮分泌的影响。β-内啡肽（β-EP）以剂量依赖方式刺激孕酮分泌（10(-8)-10(-6)mol/L）；强啡肽仅在10(-6)mol/L时表现出刺激作用，而甲硫氨酸脑啡肽在10(-10)-10(-6)mol/L剂量范围内无明显作用。μ-阿片受体激动剂DAGO和吗啡也刺激孕酮分泌。β-EP、DAGO和吗啡的刺激作用可被纳洛酮完全逆转。鉴于大鼠血浆中β-EP水平低于卵巢中的水平，β-EP似乎可能是一种卵巢内促黄体生成因子，并参与孕酮分泌的调节。β-EP的这一作用可能由μ-阿片受体亚型介导。
