Jiao K, Zhu Y L, Mei Q, Zhang W H, Wang F Z
Department of Physiology, 4th Military Medical University, Xi'an.
Sheng Li Xue Bao. 1992 Jun;44(3):310-5.
Bilateral electrical lesioning of the hippocampal CA3 region (HCA3-EL) or anterior commissura hippocampi (ACHF-EL) caused marked elevations in plasma basal levels of insulin. 2 weeks later, fasting blood glucose levels were also augmented with decreased glucose tolerance. In contrast, the secretory response of pancreatic B cells to glucose stimulation was markedly enhanced. Following intravenous glucose tolerance test (IVGTT), the relative amounts of glucagon-like and insulin-like immunoreactants were reduced in the pancreatic islets of both HCA3-EL and ACHF-EL rats in comparison with the controls. In the HCA3-EL group, the relative amounts of somatostatin-like immunoreactants and gross numbers of such immunostained cells in islets were also decreased as compared with the control. No difference was seen in pancreatic-polypeptide-like immunoreactivities as assessed by immunohistochemistry plus microphotometry method. The above results suggest strongly that HCA3 and ACHF exert a tonic inhibitory action on the insulin secretion in the rat.
海马CA3区双侧电损伤（HCA3 - EL）或海马前连合电损伤（ACHF - EL）导致血浆基础胰岛素水平显著升高。2周后，空腹血糖水平也升高，葡萄糖耐量降低。相反，胰腺β细胞对葡萄糖刺激的分泌反应显著增强。静脉葡萄糖耐量试验（IVGTT）后，与对照组相比，HCA3 - EL和ACHF - EL大鼠胰岛中胰高血糖素样和胰岛素样免疫反应物的相对含量均降低。在HCA3 - EL组中，与对照组相比，胰岛中生长抑素样免疫反应物的相对含量以及此类免疫染色细胞的总数也减少。通过免疫组织化学加显微光度法评估，胰腺多肽样免疫反应性未见差异。上述结果强烈表明，HCA3和ACHF对大鼠胰岛素分泌具有紧张性抑制作用。
