[禁食大鼠胰腺中胰高血糖素和胰岛素免疫反应性的定量变化]

[Quantitative change of glucagon and insulin immunoreactivities in the pancreas of fasting rats].

作者信息

Chen L, Zhang Y, Cao Y, Su H

机构信息

Department of Histology and Embryology, Fourth Military Medical University, Xi'an.

出版信息

Zhongguo Ying Yong Sheng Li Xue Za Zhi. 1997 Nov;13(4):359-60.

PMID:10322973

Abstract

In this study, the glucagon and insulin immunoreactivities in the fasting rat pancreas were quantitated by image analysis. The results showed that the glucagon immunoreactivity significantly decreased in fasting rats and that of insulin increased, as compared with that in normal rats. The glucagon immunoreactivity significantly increased after intravenous injection of glucose but no marked difference was found in insulin. These results suggest that the A cells of pancreas may be directly stimulated by nutrients, and the B cells in a different way.

摘要

在本研究中，通过图像分析对禁食大鼠胰腺中的胰高血糖素和胰岛素免疫反应性进行了定量。结果表明，与正常大鼠相比，禁食大鼠的胰高血糖素免疫反应性显著降低，而胰岛素免疫反应性增加。静脉注射葡萄糖后，胰高血糖素免疫反应性显著增加，但胰岛素未发现明显差异。这些结果表明，胰腺的A细胞可能直接受到营养物质的刺激，而B细胞则以不同的方式受到刺激。