Kishi R, Katakura Y, Ikeda T, Chen B Q, Miyake H
Department of Public Health, Sapporo Medical College, Japan.
Toxicol Lett. 1992 Nov;63(2):141-6. doi: 10.1016/0378-4274(92)90005-5.
Styrene was evaluated for the reproductive effects of pregnant rats and the neurochemical effects in the offspring of rats exposed during gestation. Pregnant Wistar rats were exposed to 0, 50, or 300 ppm styrene for 6 h/day during days 7 to 21 of gestation. No significant differences in the number of offspring delivered were observed between the exposed and control groups. Body weights at 1 day of age of the offspring whose mothers were exposed to styrene were significantly lower than those of the control group. Although, there were neither statistically significant differences of protein contents nor brain weights among styrene-exposed and their control offsprings of rats, analyses of neurotransmitter studies showed dose-dependent decreases of neuroamines, especially 5-HT (serotonin) and its metabolite 5HIAA (5-hydroxyindoleacetic acid) in the newborn offspring of styrene-exposed rats. The results suggest that gestational exposure to styrene at these concentrations does not produce apparent reproductive toxicity but affects the body weight of pups and causes lowering of the neurotransmitter levels in the brain.
研究评估了苯乙烯对怀孕大鼠的生殖影响以及对孕期接触苯乙烯的大鼠后代的神经化学影响。将怀孕的Wistar大鼠在孕期第7至21天期间每天暴露于0、50或300 ppm的苯乙烯中6小时。在暴露组和对照组之间，未观察到产仔数量有显著差异。母亲接触苯乙烯的后代在1日龄时的体重显著低于对照组。虽然，苯乙烯暴露组大鼠及其对照后代之间的蛋白质含量和脑重量均无统计学显著差异，但神经递质研究分析表明，苯乙烯暴露大鼠的新生后代中神经胺呈剂量依赖性减少，尤其是5-羟色胺（血清素）及其代谢物5-羟吲哚乙酸（5HIAA）。结果表明，孕期接触这些浓度的苯乙烯不会产生明显的生殖毒性，但会影响幼崽体重并导致大脑中神经递质水平降低。
