通过吸入或灌胃给予大鼠和家兔苯乙烯的致畸学评估。

Teratologic evaluation of styrene given to rats and rabbits by inhalation or by gavage.

作者信息

Murray F J, John J A, Balmer M F, Schwetz B A

出版信息

Toxicology. 1978 Dec;11(4):335-43. doi: 10.1016/s0300-483x(78)92039-5.

DOI:10.1016/s0300-483x(78)92039-5

Abstract

Pregnant Sprague-Dawley rats and New Zealand white rabbits inhaled 0, 300 or 600 ppm of styrene 7 h/day from days 6 through 15 (rats) and 6 through 18 (rabbits) of gestation. Additional groups of rats were given styrene by gavage at dose levels of 0, 90 or 150 mg/kg twice daily (0, 180 or 300 mg/kg, respectively) from days 6 through 15 of gestation. Embryotoxicity and fetotoxicity were not evident in rats or rabbits inhaling styrene or in rats given the compound orally. Maternal effects (decreased body weight gain and decreased food consumption) were noted in all groups of rats given styrene but none were observed in rabbits. No teratogenic effect was detected in either species inhaling styrene or in rats given styrene by gavage.

摘要

妊娠的斯普拉格-道利大鼠和新西兰白兔在妊娠第6天至第15天（大鼠）和第6天至第18天（兔子）期间，每天吸入7小时浓度为0、300或600 ppm的苯乙烯。另外几组大鼠在妊娠第6天至第15天期间，通过灌胃给予剂量水平为0、90或150 mg/kg的苯乙烯，每天两次（分别为0、180或300 mg/kg）。吸入苯乙烯的大鼠或兔子以及经口给予该化合物的大鼠均未出现胚胎毒性和胎儿毒性。在所有给予苯乙烯的大鼠组中均观察到母体效应（体重增加减少和食物消耗减少），但在兔子中未观察到。吸入苯乙烯的两种动物或经灌胃给予苯乙烯的大鼠均未检测到致畸作用。