Espey M J, Downie J W, Fine A
Department of Pharmacology and Physiology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
Eur J Pharmacol. 1992 Oct 6;221(1):167-70. doi: 10.1016/0014-2999(92)90788-6.
Micturition was induced in awake cats by infusing saline into the bladder at a physiological filling rate. Methysergide, a serotonergic antagonist given intrathecally, decreased the volume at which micturition occurred. Phentolamine, a non-specific alpha-adrenoceptor antagonist, also decreased volume threshold. Prazosin, an alpha 1-adrenoceptor antagonist, was without effect on micturition. These results imply that 5-HT receptors and alpha 2-adrenoceptors may be inhibitory to micturition at a spinal level.
通过以生理充盈速率向膀胱内注入生理盐水诱导清醒猫排尿。鞘内注射血清素能拮抗剂麦角新碱可降低排尿时的膀胱容量。非特异性α-肾上腺素能受体拮抗剂酚妥拉明也降低了容量阈值。α1-肾上腺素能受体拮抗剂哌唑嗪对排尿无影响。这些结果表明，5-羟色胺（5-HT）受体和α2-肾上腺素能受体在脊髓水平可能对排尿具有抑制作用。
