Espey M J, Downie J W
Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada.
Eur J Pharmacol. 1995 Dec 12;287(2):173-7. doi: 10.1016/0014-2999(95)00614-1.
Micturition was evoked in conscious cats by infusing saline into the bladder at a physiological rate. Drugs were administered intrathecally. Micturition volume threshold was increased by 5-hydroxytryptamine (5-HT, serotonin) and decreased by zatosetron, a 5-HT3 receptor antagonist, in spinally intact cats. Thus 5-HT3 receptors inhibit micturition. After complete spinal transection, serotonin reduced volume threshold in 3 of 4 cats, indicating an alteration in serotonergic control. However, 2-methyl-5-HT, a 5-HT3 receptor agonist, increased volume threshold. Thus 5-HT3 receptor-mediated inhibition of bladder function remains after spinal transection. We conclude that some, but not all, serotonergic modulation of bladder function is altered after spinal transection.
通过以生理速率向膀胱内注入生理盐水，在清醒猫身上诱发排尿。药物经鞘内给药。在脊髓完整的猫中，5-羟色胺（5-HT，血清素）使排尿量阈值升高，而5-HT3受体拮抗剂扎托司琼则使其降低。因此，5-HT3受体抑制排尿。在完全脊髓横断后，血清素使4只猫中的3只的排尿量阈值降低，表明血清素能控制发生了改变。然而，5-HT3受体激动剂2-甲基-5-HT使排尿量阈值升高。因此，脊髓横断后5-HT3受体介导的膀胱功能抑制仍然存在。我们得出结论，脊髓横断后，膀胱功能的血清素能调节部分（而非全部）发生了改变。
