向清醒大鼠的孤束核微量注射S-亚硝基半胱氨酸可降低动脉血压，但L-谷氨酸则无此作用。

Microinjection of S-nitrosocysteine into the nucleus tractus solitarii of conscious rats decreases arterial pressure but L-glutamate does not.

作者信息

Machado B H, Bonagamba L G

机构信息

Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil.

出版信息

Eur J Pharmacol. 1992 Oct 6;221(1):179-82. doi: 10.1016/0014-2999(92)90791-2.

DOI:10.1016/0014-2999(92)90791-2

PMID:1360902

Abstract

Unilateral microinjection of L-glutamate into the nucleus tractus solitarii of conscious rats increased arterial pressure and caused bradycardia while microinjection of S-nitrosocysteine into the same site of these animals caused hypotension and bradycardia. The responses to S-nitrosocysteine were blocked by prior microinjection of methylene blue into the nucleus tractus solitarii. The bradycardia and fall in arterial pressure induced by S-nitrosocysteine resemble more the cardiovascular changes in response to activation of baroreceptor afferents than the bradycardia and increase in arterial pressure induced by microinjection of L-glutamate into the nucleus tractus solitarii of conscious rats.

摘要

向清醒大鼠的孤束核单侧微量注射L-谷氨酸可升高动脉血压并引起心动过缓，而向这些动物的同一部位微量注射S-亚硝基半胱氨酸则导致低血压和心动过缓。预先向孤束核微量注射亚甲蓝可阻断对S-亚硝基半胱氨酸的反应。与向清醒大鼠孤束核微量注射L-谷氨酸所引起的心动过缓和动脉血压升高相比，S-亚硝基半胱氨酸所引起的心动过缓和动脉血压下降更类似于压力感受器传入神经激活后的心血管变化。