舒马唑对交感神经节中前列腺素E2和D-丙氨酸2-甲硫氨酸脑啡肽酰胺调节环磷酸腺苷合成及神经递质释放的影响。

Sulmazole effects on PGE2 and D-Ala2-Met-enkephalinamide modulation of cyclic AMP synthesis and neurotransmitter release in a sympathetic ganglion.

作者信息

Borasio P G, Cervellati F, Fabbri E

机构信息

Institute of General Physiology, University of Ferrara, Italy.

出版信息

Neurosci Lett. 1992 Sep 28;145(1):105-8. doi: 10.1016/0304-3940(92)90214-r.

DOI:10.1016/0304-3940(92)90214-r

PMID:1361043

Abstract

In the guinea-pig superior cervical ganglion, the Gi blocking agent sulmazole enhanced the basal and prostaglandin E2-induced stimulation of cyclic AMP synthesis but had no effect on the prostaglandin-dependent inhibition of acetylcholine release. On the contrary sulmazole counteracted the inhibitory effect of D-Ala2-Met-enkephalinamide both on cyclic AMP formation and acetylcholine release. Moreover sulmazole eliminated the supra-additive effect of the combination of prostaglandin + opiate on cyclic AMP synthesis. The presence of a Gi-coupled opiate receptor at the pre-and postsynaptic levels is suggested.

摘要

在豚鼠颈上神经节中，Gi阻断剂舒马唑增强了基础状态下以及前列腺素E2诱导的环磷酸腺苷（cAMP）合成刺激作用，但对前列腺素依赖性的乙酰胆碱释放抑制作用没有影响。相反，舒马唑抵消了D - 丙氨酸2 - 甲硫氨酸脑啡肽酰胺对cAMP形成和乙酰胆碱释放的抑制作用。此外，舒马唑消除了前列腺素 + 阿片类药物组合对cAMP合成的超相加作用。提示在突触前和突触后水平存在Gi偶联的阿片受体。