阿片类物质对哺乳动物交感神经节中环磷酸腺苷（cAMP）水平及前列腺素E2（PGE2）结合的调节作用。
Opiates modulation of cAMP levels and PGE2 binding in mammalian sympathetic ganglia.
作者信息
Borasio P G, Biondi C, Capuzzo A, Ferretti M E
出版信息
Neurosci Lett. 1986 May 6;66(1):7-12. doi: 10.1016/0304-3940(86)90157-6.
The effects of opiates on cyclic adenosine monophosphate (cAMP) levels have been studied in sympathetic ganglia of guinea-pig, rat and rabbit. D-[Ala2]-Met-enkephalinamide inhibits cAMP synthesis in guinea pig and rat but not in rabbit ganglia, while morphine is always ineffective. In the presence of the enkephalin plus prostaglandin E2 (PGE2) a synergistic increase of the nucleotide levels is observed in guinea pig. This effect is not induced by morphine plus PGE2 and is not shared by rat and rabbit. In guinea pig alpha-endorphin inhibits both basal and PGE2-stimulated cAMP synthesis. In the same preparation the enkephalin increases [3H]PGE2 binding. In guinea pig ganglia a cooperative effect of the enkephalin and PGE2 on the cAMP system is suggested.
人们已经在豚鼠、大鼠和兔子的交感神经节中研究了阿片类药物对环磷酸腺苷（cAMP）水平的影响。D-[丙氨酸²]-甲硫氨酸脑啡肽酰胺抑制豚鼠和大鼠神经节中的cAMP合成，但对兔神经节无此作用，而吗啡始终无效。在存在脑啡肽和前列腺素E2（PGE2）的情况下，在豚鼠中观察到核苷酸水平的协同增加。吗啡加PGE2不会诱导这种效应，大鼠和兔子也没有这种效应。在豚鼠中，α-内啡肽抑制基础和PGE2刺激的cAMP合成。在同一实验制剂中，脑啡肽增加[³H]PGE2结合。在豚鼠神经节中，提示脑啡肽和PGE2对cAMP系统有协同作用。
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