Pediatr Infect Dis J. 1992 Dec;11(12):1018-26.
The T lymphocyte subsets in the peripheral blood of 459 uninfected children born to white human immunodeficiency virus 1-infected women included in the European Collaborative Study were measured at regular intervals from birth. More than 2400 observations were used to create smooth age-related reference ranges for CD4 and CD8 counts and percentages, CD4:CD8 ratio and absolute lymphocyte count. Standards are presented for children up to 4 years of age. CD4, CD8 and absolute lymphocyte count rose after birth, peaked at around 6 to 9 months of age and then declined toward adult values. CD4 percentage and CD4:CD8 ratio declined steadily from birth onwards. Centile lines for CD4 count and CD4:CD8 ratio converged markedly with age. For the CD4 values, only 3 to 5% of the variation was attributable to differences between the 10 participating centers. These standards allow T lymphocyte abnormalities to be used more effectively as markers for disease progression and assist in the clinical follow up of human immunodeficiency virus 1-infected children. They also provide a basis for initiating antiretroviral treatment or antimicrobial prophylaxis.
欧洲协作研究纳入了459名母亲感染人类免疫缺陷病毒1型的未感染儿童，对其外周血中的T淋巴细胞亚群从出生起进行定期检测。超过2400次观察用于建立与年龄相关的CD4和CD8计数及百分比、CD4:CD8比值和绝对淋巴细胞计数的平滑参考范围。给出了4岁以下儿童的标准。CD4、CD8和绝对淋巴细胞计数在出生后上升，在6至9个月左右达到峰值，然后向成人值下降。CD4百分比和CD4:CD8比值从出生起稳步下降。CD4计数和CD4:CD8比值的百分位数线随年龄显著趋同。对于CD4值，只有3%至5%的变异可归因于10个参与中心之间的差异。这些标准使T淋巴细胞异常能够更有效地用作疾病进展的标志物，并有助于对感染人类免疫缺陷病毒1型儿童进行临床随访。它们还为启动抗逆转录病毒治疗或抗菌预防提供了依据。
