Proline-specific aminopeptidases: potential role in bradykinin degradation.
作者信息
Vanhoof G, de Meester I, Hendriks D, Goossens F, van Sande M, Scharpé S, Yaron A
机构信息
Laboratory of Medical Biochemistry, University of Antwerp, Wilrijk, Belgium.
出版信息
Agents Actions Suppl. 1992;38 ( Pt 2):120-7.
PMID:1361094
Abstract
The N-terminus of bradykinin is shown to be sequentially degraded by the human proline-specific aminopeptidases aminopeptidase P (EC 3.4.11.9) and dipeptidyl peptidase IV (EC 3.4.14.5). Additional evidence is provided for the hypothesis that these proline-specific aminopeptidases play an essential role in the degradation of peptides containing an N-terminal Xaa-Pro sequence.
摘要
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