卡巴胆碱对离体灌注大鼠十二指肠腔内生长抑素释放的影响。

Effect of carbachol on luminal release of somatostatin from isolated perfused rat duodenum.

作者信息

Fujimiya M, McIntosh C H, Kimura H, Kwok Y N

机构信息

Department of Anatomy, Shiga University of Medical Science, Japan.

出版信息

Neurosci Lett. 1992 Oct 12;145(2):229-33. doi: 10.1016/0304-3940(92)90029-7.

DOI:10.1016/0304-3940(92)90029-7

PMID:1361226

Abstract

The dynamic release of somatostatin-like immunoreactivity (SLI) from duodenum into the lumen was studied in the isolated, vascularly perfused rat duodenum. The luminal release of duodenal SLI was stimulated by a cholinergic agonist, carbachol, and the carbachol-induced release of SLI was completely blocked by atropine, but not by hexamethonium. These data suggest that the luminal release of SLI from rat duodenum is under the control of a cholinergic muscarinic stimulation. The ratio of somatostatin-14 to somatostatin-28 in picograms was about 1 during basal release but increased to approximately 2 during carbachol stimulation.

摘要

在离体、血管灌注的大鼠十二指肠中研究了十二指肠中生长抑素样免疫反应性物质（SLI）向肠腔的动态释放。十二指肠SLI的肠腔释放受到胆碱能激动剂卡巴胆碱的刺激，卡巴胆碱诱导的SLI释放被阿托品完全阻断，但六甲铵不能阻断。这些数据表明，大鼠十二指肠中SLI的肠腔释放受胆碱能毒蕈碱刺激的控制。在基础释放期间，生长抑素-14与生长抑素-28的皮克比约为1，但在卡巴胆碱刺激期间增加到约2。