Alm A, Berggren L
Institutionen för oftalmiatrik, Ogonkliniken, Akademiska Sjukhuset, Uppsala.
Nord Med. 1992;107(12):306-8, 318.
The aim of all treatment for glaucoma is to lower intra-ocular pressure. During the past decade, the short-action cholinergic agonists, eserine and pilocarpine, that have been used for over a hundred years have been replaced as the drugs of choice by beta-blockers, in particular the non-selective beta-blocker, timolol maleate. Of the series of drugs developed in recent years for the treatment of glaucoma, two types--carbonic anhydrase inhibitors and prostaglandin analogues--are undergoing phase III trials. The article provides an account of the pharmacological basis of glaucoma treatment today and in the immediate future.
青光眼所有治疗的目的都是降低眼压。在过去十年中,已使用了一百多年的短效胆碱能激动剂毒扁豆碱和毛果芸香碱,已被β受体阻滞剂,特别是非选择性β受体阻滞剂马来酸噻吗洛尔,取代为首选药物。近年来开发的用于治疗青光眼的一系列药物中,有两类——碳酸酐酶抑制剂和前列腺素类似物——正在进行III期试验。本文介绍了当今及不久的将来青光眼治疗的药理学基础。