Realini Tony
Department of Ophthalmology, West Virginia University Eye Institute, West Virginia University, Morgantown, West Virginia 26505, USA.
Optom Vis Sci. 2011 Jan;88(1):36-8. doi: 10.1097/OPX.0b013e3182058ead.
The history of glaucoma pharmacology begins in 1862 with the isolation of physostigmine from the calabar bean. The discovery of epinephrine's intraocular pressure lowering capacity came along some 40 years later. During the 20th century, drug discovery and development accelerated, with the introduction of carbonic anhydrase inhibitors, beta blockers, and prostaglandin analogs. This survey of the history of glaucoma medications reviews some of the pivotal stories behind the development of the drugs that we use daily to manage our patients with glaucoma. In addition, some unmet needs that persist in glaucoma pharmacology are discussed.
青光眼药理学的历史始于1862年，当时从毒扁豆中分离出了毒扁豆碱。大约40年后发现了肾上腺素降低眼压的能力。在20世纪，随着碳酸酐酶抑制剂、β受体阻滞剂和前列腺素类似物的引入，药物研发加速。本文对青光眼药物治疗史进行了综述，回顾了我们日常用于治疗青光眼患者的药物研发背后的一些关键故事。此外，还讨论了青光眼药理学中一些尚未满足的需求。
