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Onset and recovery of rocuronium (Org 9426) and vecuronium under enflurane anaesthesia.

作者信息

Mayer M, Doenicke A, Hofmann A, Peter K

机构信息

Institute of Anaesthesiology, LMU München, Innenstadtkliniken, Germany.

出版信息

Br J Anaesth. 1992 Nov;69(5):511-2. doi: 10.1093/bja/69.5.511.

DOI:10.1093/bja/69.5.511
PMID:1361356
Abstract

We have studied the onset, duration of action and recovery index of twice the ED90 of rocuronium (Org 9426) (0.6 mg kg-1) and of vecuronium (0.08 mg kg-1) in patients during enflurane anaesthesia. Rocuronium had a significantly shorter mean onset time of 1.8 (SD 0.4) min, compared with vecuronium 3.4 (0.8) min. Clinical duration (time for the first twitch in the train-of-four to recover to 25% of control) was similar for both drugs (29 (10) min vs 31 (12) min). Spontaneous recovery times (TOF ratio 70%) did not differ significantly between rocuronium (47 (10) min) and vecuronium (44 (11) min).

摘要

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