Shinoda S, Kondo N, Fukutomi O, Agata H, Orii T
Department of Pediatrics, Gifu University School of Medicine, Japan.
Acta Paediatr. 1992 Nov;81(11):896-901. doi: 10.1111/j.1651-2227.1992.tb12131.x.
Proliferative responses of peripheral blood mononuclear cells and T cells with monocytes to ovalbumin were significantly higher than those of B cells with monocytes to ovalbumin in patients with atopic dermatitis (AD) who were sensitive to hen eggs. The CD4+ T-cell/CD8+ T-cell ratios (the values obtained by dividing the maximum stimulation index of CD4+ T cells with monocytes to ovalbumin by the maximum stimulation index of CD8+ T cells with monocytes to ovalbumin) were significantly higher in AD patients sensitive to hen eggs than in non-atopic healthy controls. The proliferative responses of CD4+ T cells with monocytes to ovalbumin were more intensive than those of CD8+ T cells with monocytes in patients with AD sensitive to hen eggs compared with non-atopic healthy controls. These results suggest that the cells responding to ovalbumin are predominantly CD4+ T cells. However, there was no relationship between the stimulation index of proliferative responses of peripheral blood mononuclear cells to ovalbumin and RAST scores for hen eggs. Thus it is possible that the majority of the CD4+ T cells which respond to ovalbumin are not CD4+ helper T cells for IgE production.
在对鸡蛋敏感的特应性皮炎（AD）患者中，外周血单个核细胞以及单核细胞存在时T细胞对卵清蛋白的增殖反应显著高于单核细胞存在时B细胞对卵清蛋白的增殖反应。对鸡蛋敏感的AD患者中，CD4⁺ T细胞/CD8⁺ T细胞比值（通过将单核细胞存在时CD4⁺ T细胞对卵清蛋白的最大刺激指数除以单核细胞存在时CD8⁺ T细胞对卵清蛋白的最大刺激指数得到的值）显著高于非特应性健康对照。与非特应性健康对照相比，对鸡蛋敏感的AD患者中，单核细胞存在时CD4⁺ T细胞对卵清蛋白的增殖反应比CD8⁺ T细胞更强烈。这些结果表明，对卵清蛋白产生反应的细胞主要是CD4⁺ T细胞。然而，外周血单个核细胞对卵清蛋白的增殖反应刺激指数与鸡蛋的RAST评分之间没有关联。因此，有可能大多数对卵清蛋白产生反应的CD4⁺ T细胞并非产生IgE的CD4⁺辅助性T细胞。
