Kondo N, Shinbara M, Inoue R, Fukao T, Kaneko H, Teramoto T, Tashita H
Department of Pediatrics, Gifu University School of Medicine, Japan.
J Investig Allergol Clin Immunol. 1997 Jul-Aug;7(4):225-8.
Procaterol hydrochloride is a relatively new beta 2-selective agonist with a unique carbostyril nucleus. In this study, procaterol dose-dependently inhibited IFN-gamma production of peripheral blood mononuclear cells stimulated with ovalbumin in patients with hen's egg-sensitive atopic dermatitis, without inhibition of proliferative responses of peripheral blood mononuclear cells. Our results suggest that procaterol also has an effect as an immunomodulator, in addition to its effect as a beta 2-selective agonist.
盐酸丙卡特罗是一种相对较新的β2选择性激动剂，具有独特的喹啉核。在本研究中，盐酸丙卡特罗剂量依赖性地抑制了鸡蛋敏感型特应性皮炎患者外周血单核细胞在卵清蛋白刺激下产生γ干扰素，而不抑制外周血单核细胞的增殖反应。我们的结果表明，盐酸丙卡特罗除了具有β2选择性激动剂的作用外，还具有免疫调节剂的作用。
