Rowland N E
Department of Psychology, University of Florida, Gainesville 32611-2065.
Brain Res. 1992 Nov 13;595(2):291-4. doi: 10.1016/0006-8993(92)91062-j.
Rats were injected acutely with antimetabolites of either glucose (2 deoxy-D-glucose, 2DG), fat (methylpalmoxirate, MP or mercaptoacetate, MAC), or the combination of these agents, in dosages known to stimulate food intake. Norepinephrine (NE) turnover in hypothalamus and brainstem was determined after these treatments by the method of synthesis inhibition. Glucoprivation (2DG) increased NE turnover in hypothalamus, confirming previous studies. Fat antimetabolites alone had no effect on NE turnover, nor did a peripherally-acting fructose antimetabolite. Combination of MP and 2DG, but not MAC and 2DG, produced a greater NE turnover than 2DG alone. These data suggest that peripheral signals of metabolic emergency do not activate brain NE systems, except when these systems are already activated by an ongoing cerebral metabolic emergency. The role of hypothalamic NE in metabolic integration of feeding is discussed, and possible hemispheric differences.
给大鼠急性注射已知能刺激食物摄入剂量的葡萄糖（2-脱氧-D-葡萄糖，2DG）、脂肪（甲基棕榈酰肉碱，MP或巯基乙酸，MAC）的抗代谢物，或这些药物的组合。通过合成抑制法测定这些处理后下丘脑和脑干中去甲肾上腺素（NE）的周转率。糖剥夺（2DG）增加了下丘脑NE的周转率，证实了先前的研究。单独使用脂肪抗代谢物对NE周转率没有影响，外周作用的果糖抗代谢物也没有影响。MP和2DG的组合，而不是MAC和2DG的组合，比单独使用2DG产生了更高的NE周转率。这些数据表明，代谢紧急情况的外周信号不会激活脑NE系统，除非这些系统已经被正在发生的脑代谢紧急情况激活。讨论了下丘脑NE在进食代谢整合中的作用以及可能的半球差异。
