Manning P A
Department of Microbiology and Immunology, University of Adelaide, South Australia.
Vaccine. 1992;10(14):1015-21. doi: 10.1016/0264-410x(92)90110-6.
Cholera is still a serious public health problem in developing countries, particularly those in tropical regions. This has stimulated considerable research into the molecular analysis of pathogenesis resulting in the identification of a number of critical components required for both colonization of the gut mucosa and the disease symptoms. These components are the targets for rational molecular approaches to vaccine development.
霍乱在发展中国家，尤其是热带地区的国家，仍然是一个严重的公共卫生问题。这激发了对发病机制分子分析的大量研究，从而确定了肠道黏膜定植和疾病症状所需的一些关键成分。这些成分是合理的分子疫苗开发方法的靶点。
