绵羊中由丙二醇引起的血红蛋白尿。
Haemoglobinuria caused by propylene glycol in sheep.
作者信息
POTTER B J
出版信息
Br J Pharmacol Chemother. 1958 Dec;13(4):385-9. doi: 10.1111/j.1476-5381.1958.tb00225.x.
HAEMOGLOBINURIA OCCURRED IN SHEEP ANAESTHETIZED BY AN INTRAVENOUS INJECTION OF PENTOBARBITONE SODIUM CONTAINING PROPYLENE GLYCOL
an equivalent dose failed to cause haemoglobinuria in rabbits. Intravenous injection of an aqueous solution of 20% propylene glycol caused haemoglobinaemia and haemoglobinuria in sheep. Neither distilled water nor 20% glycerol in water administered under identical conditions produced these effects.Haemoglobinuria occurred on some occasions when an aqueous 20% solution of propylene glycol was administered to sheep after an injection of saline: it never occurred when a solution of 20% propylene glycol prepared with physiological saline was injected. It is suggested that saline may protect against the haemolytic action of propylene glycol in sheep and that propylene glycol should be avoided as a menstruum for pharmaceutical preparations to be used for injection into the blood stream of these animals.
静脉注射含丙二醇的戊巴比妥钠麻醉绵羊时出现血红蛋白尿
同等剂量对兔子未造成血红蛋白尿。静脉注射20%丙二醇水溶液可导致绵羊出现血红蛋白血症和血红蛋白尿。在相同条件下给予蒸馏水或20%甘油水溶液均未产生这些效应。在给绵羊注射生理盐水后给予20%丙二醇水溶液时，有时会出现血红蛋白尿：而注射用生理盐水配制的20%丙二醇溶液时则从未出现。提示生理盐水可能可保护绵羊免受丙二醇的溶血作用，并且应避免将丙二醇用作注射到这些动物血流中的药物制剂的溶媒。
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