Das Gupta V
J Pharm Sci. 1984 Nov;73(11):1661-2. doi: 10.1002/jps.2600731149.
The effects of ethanol, glycerol, propylene glycol, phosphate buffer, and ionic strength on the stability of phenobarbital sodium have been studied. Ethanol had the maximum stabilization effect followed by propylene glycol and glycerol when compared with the stability in water. The estimated half-lives at 50 degrees C (pH approximately 8) were 78, 95, 109, and 127 d in water and 20% aqueous solutions of glycerol, propylene glycol, and ethanol, respectively. The effects of phosphate buffer and ionic strength were negligible.
已研究了乙醇、甘油、丙二醇、磷酸盐缓冲液和离子强度对苯巴比妥钠稳定性的影响。与在水中的稳定性相比，乙醇具有最大的稳定作用，其次是丙二醇和甘油。在50℃（pH约为8）时，在水中以及甘油、丙二醇和乙醇的20%水溶液中的估计半衰期分别为78、95、109和127天。磷酸盐缓冲液和离子强度的影响可忽略不计。
