硫代硫酸钠和硫代柠檬酸对白化大鼠芥子气（二（2-氯乙基）硫醚）全身中毒的防护作用
Protection against systemic poisoning by mustard gas, di(2-chloroethyl) sulphide, by sodium thiosulphate and thiocit in the albino rat.
作者信息
CALLAWAY S, PEARCE K A
出版信息
Br J Pharmacol Chemother. 1958 Dec;13(4):395-8. doi: 10.1111/j.1476-5381.1958.tb00227.x.
The lethal effects of mustard gas, di(2-chloroethyl) sulphide, in the albino rat have been counteracted by Thiocit, a mixture of sodium thiosulphate and trisodium citrate in the ratio 10:1, administered intraperitoneally in a dose of 2.75 g./kg. Thiocit afforded complete protection against greater than the median lethal dose of mustard gas whether given 10 min. before or 10 min. after mustard gas and raised the LD50 of mustard gas by approximately three times. The protection appeared whether the total dose of Thiocit was given in one injection or serially over 30 min. The effective doses of sodium thiosulphate and of Thiocit in rats were of the order of 3.0 g./kg. Sodium thiosulphate alone and Thiocit have been administered in single doses by slow infusion, by stomach tube and in drinking water. Both have shown activity by all routes of administration, but activity was greatest by intraperitoneal injection. The use of Thiocit in conjunction with mustard gas therapy is suggested.
硫代柠檬酸盐（Thiocit）是一种由硫代硫酸钠和柠檬酸三钠按10:1比例混合而成的物质，以2.75克/千克的剂量腹腔注射，可抵消芥子气（二（2-氯乙基）硫化物）对白化大鼠的致死作用。无论在芥子气注射前10分钟还是注射后10分钟给予硫代柠檬酸盐，它都能为大鼠提供完全保护，使其免受大于半数致死剂量的芥子气侵害，并且将芥子气的半数致死剂量提高了约三倍。无论硫代柠檬酸盐的总剂量是一次性注射还是在30分钟内分次注射，都能起到保护作用。硫代硫酸钠和硫代柠檬酸盐在大鼠中的有效剂量约为3.0克/千克。硫代硫酸钠单独使用以及硫代柠檬酸盐都已通过缓慢输注、胃管给药和饮水等方式进行单剂量给药。两种给药方式都显示出活性，但腹腔注射的活性最大。建议将硫代柠檬酸盐与芥子气疗法联合使用。
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