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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Gow C B, Silvapulle M J, Moore G P

School of Agriculture, La Trobe University, Bundoora, Victoria, Australia.

Comp Biochem Physiol Comp Physiol. 1992 Dec;103(4):687-93. doi: 10.1016/0300-9629(92)90167-o.

Lactating ewes were treated with mouse epidermal growth factor (EGF) at a dose rate of 0.5 mg/day for 4 days and its effects on the electrolyte profile were observed. 2. There was no effect of EGF on plasma concentrations of sodium or potassium, although urinary and total (in urine and milk) losses of both were reduced. 3. EGF-induced hypocalcaemia was associated with reduced milk calcium secretion and increased urinary calcium excretion whereas EGF-induced hypermagnesaemia was associated with reduced urinary and total magnesium losses. 4. Glomerular filtration rate was reduced during EGF infusion. 5. Chronic intravenous EGF infusion affects the electrolyte profile by altering electrolyte secretion by the mammary gland and renal electrolyte excretion.

给泌乳母羊以0.5毫克/天的剂量率注射小鼠表皮生长因子（EGF），持续4天，并观察其对电解质状况的影响。2. EGF对血浆钠或钾浓度没有影响，尽管两者的尿排泄量和总排泄量（尿和乳中的）均有所减少。3. EGF诱导的低钙血症与乳钙分泌减少和尿钙排泄增加有关，而EGF诱导的高镁血症与尿镁和总镁排泄减少有关。4. 在输注EGF期间，肾小球滤过率降低。5. 长期静脉输注EGF通过改变乳腺电解质分泌和肾脏电解质排泄来影响电解质状况。

Gow C B, Silvapulle M J, Moore G P

School of Agriculture, La Trobe University, Bundoora, Victoria, Australia.

Comp Biochem Physiol Comp Physiol. 1992 Dec;103(4):687-93. doi: 10.1016/0300-9629(92)90167-o.

Lactating ewes were treated with mouse epidermal growth factor (EGF) at a dose rate of 0.5 mg/day for 4 days and its effects on the electrolyte profile were observed. 2. There was no effect of EGF on plasma concentrations of sodium or potassium, although urinary and total (in urine and milk) losses of both were reduced. 3. EGF-induced hypocalcaemia was associated with reduced milk calcium secretion and increased urinary calcium excretion whereas EGF-induced hypermagnesaemia was associated with reduced urinary and total magnesium losses. 4. Glomerular filtration rate was reduced during EGF infusion. 5. Chronic intravenous EGF infusion affects the electrolyte profile by altering electrolyte secretion by the mammary gland and renal electrolyte excretion.

给泌乳母羊以0.5毫克/天的剂量率注射小鼠表皮生长因子（EGF），持续4天，并观察其对电解质状况的影响。2. EGF对血浆钠或钾浓度没有影响，尽管两者的尿排泄量和总排泄量（尿和乳中的）均有所减少。3. EGF诱导的低钙血症与乳钙分泌减少和尿钙排泄增加有关，而EGF诱导的高镁血症与尿镁和总镁排泄减少有关。4. 在输注EGF期间，肾小球滤过率降低。5. 长期静脉输注EGF通过改变乳腺电解质分泌和肾脏电解质排泄来影响电解质状况。