Wood P L, Ryan R, Li M
Dept. of Pharmacology, Mayo Clinic Jacksonville, FL 32224.
Life Sci. 1992;51(26):PL267-70. doi: 10.1016/0024-3205(92)90163-j.
As previously reported, intracerebellar injections of D-serine, quisqualate and kainate elevated mouse cerebellar cGMP levels. Similarly, activation of endogenous excitatory amino acid utilizing neurons with harmaline or pentylenetetrazole also increased cerebellar cGMP. We previously have demonstrated that the harmaline- and pentylenetetrazol-dependent cGMP increases are NMDA receptor mediated. In this report we further demonstrate that NMDA-dependent increases in cGMP are dependent upon monoaminergic innervation of the cerebellum, while kainate- and quisqualate-dependent cGMP increases are independent of such innervation.
如先前报道，向小鼠小脑内注射D-丝氨酸、quisqualate和海藻酸可提高小鼠小脑的环磷酸鸟苷（cGMP）水平。同样，用槟榔碱或戊四氮激活内源性利用兴奋性氨基酸的神经元也会增加小脑的cGMP。我们之前已经证明，槟榔碱和戊四氮依赖的cGMP增加是由N-甲基-D-天冬氨酸（NMDA）受体介导的。在本报告中，我们进一步证明，NMDA依赖的cGMP增加依赖于小脑的单胺能神经支配，而海藻酸和quisqualate依赖的cGMP增加则不依赖于这种神经支配。
