钆对N-甲基-D-天冬氨酸（NMDA）诱导的中枢性心律失常的影响。
Effects of gadolinium on N-methyl-D-aspartate (NMDA)-induced centrogenic arrhythmias.
作者信息
Berrino L, De Novellis V, Maione S, Cuparencu B, Rossi F
机构信息
Institute of Pharmacology and Toxicology, First Faculty of Medicine and Surgery, University of Naples, Italy.
出版信息
Res Commun Chem Pathol Pharmacol. 1992 Nov;78(2):219-23.
PMID:1362004
Abstract
In urethane-anesthetized rats, the intracerebroventricular (i.c.v.) administration of N-methyl-D-aspartate (NMDA)-induced central arrhythmias. These cardiac rhythm disorders could be prevented by the i.c.v. microinjection of gadolinium, an inhibitor of exocytosis. These findings suggest that inhibition of central neurotransmitter exocytosis could protect against centrogenic arrhythmias.
摘要
在氨基甲酸乙酯麻醉的大鼠中，脑室内（i.c.v.）注射N-甲基-D-天冬氨酸（NMDA）可诱发中枢性心律失常。胞吐作用抑制剂钆的脑室内微量注射可预防这些心律失常。这些发现表明，抑制中枢神经递质的胞吐作用可预防中枢性心律失常。
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